Antibodies, proteins and peptides
Obtain affinity and kinetics of your antibody, protein or peptide by following their binding in real-time
Proteins and peptides are essential for life as we know it and they act by interacting with other molecules. LigandTracer opens up for a wide range of possibilities, such as detailed characterization of biopharmaceutical drug candidates, investigation of avidity effects and thorough understanding of receptor systems.
Key Applications
- Estimate kinetics and affinity
- Investigate specificity and competitive properties
- Study dimerization and clustering processes
- Evaluate how conjugations affect the ligand
- Alter temperature and monitor the outcome
Key publications
These publications illustrate the application well. Here are more examples for Antibodies, Proteins and Peptides.
Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent.
Bondza S, Ten Broeke T, Nestor M, Leusen JHW, Buijs J.
MAbs. 2020. 12(1):1792673.
Summary
PubMed
Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts.
Garousi J, Huizing FJ, Vorobyeva A, Mitran B, Andersson KG, Dahlsson Leitao C, Frejd FY, Löfblom J, Bussink J, Orlova A, Heskamp S, Tolmachev V.
Sci Rep. 2019. 9:14907.
Summary
PubMed
Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model.
Mitran B, Güler R, Roche FP, Lindström E, Selvaraju RK, Fleetwood F, Rinne SS, Claesson-Welsh L, Tolmachev V, Ståhl S, Orlova A, Löfblom J.
Theranostics. 2018. 8(16):4462-4476.
Summary
PubMed
Examples of ligands
