Small molecules
Characterize interaction properties of small molecules
Investigate the binding of low molecular weight compounds, such as drugs, FDG and DNA bases. The label is a radioactive isotope (e.g.,18F) replacing its non-radioactive counterpart during synthesis, which ensures that the interaction properties of the molecule are not affected.
Key applications
- Estimate kinetics and affinity
- Investigate specificity and competitive properties
- Follow DNA synthesis over time
- Characterize radiotracers
- Alter temperature and monitor the outcome
Key publications
These publications illustrate the application well. Click here for more examples.
[18F]FEPPA: Improved automated radiosynthesis, binding affinity and preliminary in vitro evaluation in colorectal cancer.
Berroterán-Infante N, Balber T, Fürlinger P, Bergmann M, Lanzenberger R, Hacker M, Mitterhauser M, Wadsak W.
ACS Med Chem Lett. 2018. 9(3):177-181.
Summary
PubMed
The Elusive Link Between Cancer FDG Uptake and Glycolytic Flux Explains the Preserved Diagnostic Accuracy of PET/CT in Diabetes.
Cossu V, Bauckneht M, Bruno S, Orengo AM, Emionite L, Balza E, Castellani P, Piccioli P, Miceli A. Raffa S, Borra A, Donegani MI, Carlone S, Morbelli S, Ravera S, Sambuceti G, Marini C.
Transl Oncol. 2020. 13(5):100752.
Summary
PubMed
Examples of ligands
